Thyroxine-protein interactions. Interaction of thyroxine and triiodothyronine with human thyroxine-binding globulin.

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Thyroxine-protein interactions. Interaction of thyroxine and triiodothyronine with human thyroxine-binding globulin.

The effect of temperature on the binding of thyroxine and triiodothyronine to thyroxine-binding globulin has been studied by equilibrium dialysis. Inclusion of ovalbumin in the dialysis mixture stabilized thyroxine-binding globulin against losses in binding activity which had been found to occur during equilibrium dialysis. Ovalbumin by itself bound the thyroid hormones very weakly and its bind...

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Thyroxine-Binding Globulin Concentrations

Plasma thyroid hormone concentrations may be abnormal in non-thyroid disease and pose diagnostic problems. For example, concentrations of triiodothyronine (T3) in the blood decline in acute illness with a reciprocal increase in reverse triiodothyronine (reverse T3), but thyroxine (T4) concentrations are usually normal or only slightly decreased (1, 2). However, McLarty et al. (3) reported that ...

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Familial thyroxine-binding globulin deficiency.

Genetically determined thyroxine-binding globulin deficiency is described in two families in the United Kingdom. All subjects in both pedigrees were euthyroid. Transmission was by sex-linkage; males showed low serum protein bound iodine and high thyroxine (T4) resin uptake due to complete absence of serum thryroxine-binding globulin; females were less severely affected. The distinctive biochemi...

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Studies on Human Thyroxine - Binding Globulin

to large volumes of serum may be due to adsorption of neuraminidases to the Sepharose either directly from serum or as the result of bacterial contamination. Partial desialylation of TBG in vivo may be an early step in the catabolism of this protein.

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Effects of triiodothyronine and other thyroxine analogues on thyroxine-binding in human serum.

The strong affinity between thyroxine and the specific thyroxine-binding protein (TBP) of human serum (1) is apparent from, a) the inability to remove more than small amounts of thyroxine from the serum by prolonged dialysis (2), and b) the effectiveness with which TBP competes with albumin for available thyroxine in serum, despite its much smaller concentration. Thyroxine bound to TBP is, neve...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1976

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(17)33380-x